Translational research links scientific findings with programs and policies that improve human health and well-being. It includes research that evaluates interventions or policies for efficacy and effectiveness, as well as research that applies field experience to future development of basic theory and its applications.
Although translational research has traditionally emphasized biomedical studies with one type of application (i.e., individual-level intervention to treat disease), the concept has expanded to include various sciences and many types of applications.
Social and behavioral sciences now often contribute to public- and individual-level interventions that promote education, disease prevention, health care delivery, health care access, and more. This broader, more inclusive approach to translational research has gained popularity and been promoted by the National Institutes of Health, the Centers for Disease Control, medical centers, and university programs.
This book demonstrates how emerging methods of translational research can be applied to important topics of interest to social and behavioral scientists. Accessible models and real-world case studies are provided to help bridge the gaps among research, policy, and practice.
Whether the decision is to have unprotected sex, consent to surgery, spend rather than save for retirement, or have an extra piece of pie, risky decisions permeate our lives, sometimes with disastrous consequences. How and why risk taking occurs has important implications, yet many questions remain about how various factors influence decision-making.
This book advances basic understanding and scientific theory about the brain mechanisms underlying risky decision making, paving the way for translation of science into practice and policy. This compelling research topic crosses a number of disciplines, including social, cognitive, and affective (emotion) neuroscience psychology, brain sciences, law, behavioral economics, and addiction.
Learning Objectives of the course:
Describe the processes that govern risky decision-making.
Evaluate recent research on neurobiological and psychological theory that underlie risky decision-making, including recent theory on triple processing.
Identify the differences that underlie decision making in childhood, adolescence and older adulthood.
Although older adults face significant health challenges, they tend to have better emotion regulation skills than younger or middle-age adults. Why is this so? And how might we use this knowledge to promote better health and well-being in adulthood and later life?
This book explores the reciprocal relations between aging and emotion, as well as applications for promoting mental and physical health across the lifespan. The authors discuss the neural and cognitive mechanisms behind age-related shifts in affective experience and processing.
In addition to presenting emotion regulation strategies for offsetting age-related declines in mental and physical functioning, the book examines the role of culture and motivation in shaping emotional experience across the lifespan, as well as the factors defining boundary conditions between human illness and human flourishing in old age.
By highlighting these major advances in interdisciplinary research, the authors suggest promising avenues for intervention.
Learning Objectives:
Describe the reciprocal relations between aging and emotion.
Explain the neural and cognitive mechanisms behind age-related shifts in affective experience and processing.
Apply emotion regulation strategies to offset age-related declines in mental and physical functioning.
Although older adults face significant health challenges, they tend to have better emotion regulation skills than younger or middle-age adults. Why is this so? This book explores the reciprocal relations between aging and emotion, as well as applications for promoting mental and physical health across the lifespan. The authors discuss the neural and cognitive mechanisms behind age-related shifts in affective experience and processing. In addition to presenting emotion regulation strategies for offsetting age-related declines in mental and physical functioning, the book examines the role of culture and motivation in shaping emotional experience across the lifespan, as well as the factors defining boundary conditions between human illness and human flourishing in old age.
Risky choices about sex, drugs and drinking, as well as diet, exercise, money and health care pervade our lives and can have dire consequences. Now, a new book aims to help us understand the neural roots of bad decisions. The Neuroscience of Risky Decision Making (APA Books) synthesizes the research in this relatively young field for the first time, and introduces new models of brain function to explain and predict risky behavior.
The harm caused by risky decision-making is enormous understanding how the brain processes risks and rewards is the key to unraveling the mystery of irrational decision-making in real life, said Valerie Reyna, Lois and Melvin Tukman Professor of Human Development, Director of the Human Neuroscience Institute in the College of Human Ecology and the Cornell MRI Facility.
We anticipate this work will transform the next phase of research in the field and inform policy and practice innovations that can save lives and improve health and well-being, said Reyna, who co-edited the volume with Vivian Zayas, associate professor of psychology at Cornell.
In the book, leading neuroeconomists, neuroscientists and social scientists discuss recent findings on why people take risks and how risky choices shift in different circumstances and across the life span.
The Department of Human Development commended the graduating seniors of 2017 who made exceptional contributions to research and outreach.
The Henry Ricciuti Award for Outstanding Seniors in Human Development
Front row, left: Brian LaGrant, Angel Khuu, Prof. Elaine Wethington, Joanna Ezratty, Danielle Weinstein Center row, left: Emily Hagen, Ben Zang, Prof. Qi Wang, Assoc. Prof. Eve De Rosa Back row, left: Assoc. Prof. Adam Anderson, Prof. Robert Sternberg, Marcos Moreno, Sharnendra Sidhu, Assoc. Prof. Corinna Loeckenhoff, Deaven Winebrake (Not pictured: Anna Claire G. Fernández)
Ten graduating Human Development seniors received the Henry Ricciuti Award for having achieved "distinction in research, excellence in leadership, and/or have contributed to exceptional community and public service during their undergraduate career at Cornell University." Dr. Ricciuti taught at Cornell for 53 years and was an expert in the cognitive and emotional development of infants and children and mentored many students in human development.
The Janet and Joseph Zuckerman Award for Excellence in Human Development Studies
From left: Prof. Elaine Wethington, Brian LaGrant, Assoc. Prof. Eve De Rosa, Prof. Anthony Ong
The Janet and Joseph Zuckerman Award is given to a senior whose honor's thesis is judged by HD faculty to be the most outstanding of the year. Brian LaGrant wrote “Individual Differences in Perspective Taking with Interactive Social Learning” and was advised by Dr. Eve De Rosa. Here is the abstract from his thesis:
Imitation and perspective taking have been studied extensively independently, but little research has examined how they can impact one other. The purpose of this study was to determine how one’s perspective on a model performing a behavior can impact how veridically the observer imitates the behavior, and whether individual differences in autistic traits can mediate this relationship. 57 young adults and 29 young children were randomly assigned to observe a model open a puzzle box from one of three perspectives (0º, 90º, or 180º relative to model). All participants then attempted to open it from the model’s perspective. Surprisingly, perspective did not affect success rate or overimitation, but did show an unexpected effect on reaction time in adults. As predicted, autistic traits score did mediate some outcomes among individuals in the 90º and 180º conditions. Lowtrait adults had significantly more success at opening the puzzle box than hightrait adults. Moreover, the perspective from which participants desired to open the box was accurately predicted as a function of autistic traits: high-trait children were more likely to choose the perspective they initially observed from, whereas low-trait children were more likely to pick another perspective. The findings suggest that although the perspective from which one watches someone else solve a novel task does not substantially guide task performance, individuals with high levels of autistic traits can exhibit, and might be unconsciously aware of, deficits in imitation and perspective taking. Key implications of these results are discussed.
The Urie Bronfenbrenner Awards for Achievement in Research
From left: Prof. Qi Wang, Angel Khuu, Sharnendra Sidhu, Assoc. Prof. Corinna Loeckenhoff
The Urie Bronfenbrenner Award was presented to two students who demonstrated excellence in research. Urie Bronfenbrenner taught at Cornell for over 50 years and was a highly influential developmental psychologist famous for his holistic approach to human development. Angel Khuu received the award for her research project, "How Do you Remember More Accurately? Young Adults Postdating Earliest Childhood Memories " and was advised by Dr. Wang. Here is the abstract from her thesis:
Thirty-two young adults were recruited on SONA, a Cornell University Psychology Experiment Sign-up system. They reported their five earliest memories and the properties of these memories (i.e. personal significance). Parents were then contacted to confirm these memories and dating estimates, and to provide any additional details. Consistent with the first hypothesis, these young adults postdated memories before 48 months and predated memories after 48 months. Furthermore, more dating techniques was associated with less dating error and the most frequently used techniques were seasons, school year, and landmark events, consistent with my second hypothesis. Finally, memories with landmark events were not different in dating error from memories without, evidence against the third. This study is the first to examine postdating effects in young adults. These findings have important implications on autobiographical processes.
Sharnendra Sidhu also received the Bronfenbrenner award for her research project, "Racial and Ethnic Differences in Pain Self-Management Techniques Among Older Adults with Chronic Pain" and was adivsed by Dr. Loeckenhoff. Here is the abstract from her thesis:
The literature suggests that the adoption and use of pain-management techniques varies across racial and ethnic groups. However, potential mechanisms for the observed differences remain unclear. The present study wished to determine whether the Theory of Planned Behavior (TPB) could predict the use of two types of self-management techniques, exercise and psychological strategies, among White, Black, and Hispanic older adults with chronic pain (n = 134). Thus, we examined participants’ attitudes, perceived control, implementation intentions, and usage of these two techniques as well as the influence of race/ethnicity on this model. The results were consistent with the TPB, however race/ethnicity only showed to be a main effect on exercise usage. The implications and limitations of this study will be discussed in order to provide suggestions for future research.
Honors in Human Development
Front row, left: Professor Elaine Wethington, Professor Anthony Ong Back row, left: Leona Sharpstene, Brian LaGrant, Angel Khuu, Sharnendra Sidhu, Deaven Winebrake, Hsiang Ling Tsai (Not pictured: Anna Claire G. Fernández)
The following seniors received Honors in Human Development having completed original, empirical research, and wrote and defended a honors thesis: Anna Claire G. Fernández, Angel Khuu, Brian LeGrant, Sharnendra Sidhu, Leona Sharpstene, Hsiang Ling Tsai, and Deaven Winebrake.
Congratulations to all of the 2017 Human Development graduates!
Valerie Reyna and Evan Wilhelms developed a new questionnaire for predicting who is likely to engage in risky behaviors, including, unprotected sex and binge drinking. Their questionnaire significantly outperforms 14 other gold-standard measures frequently used in economics and psychology.
The research of Professor Nathan Spreng and his collaborators sheds light on the basal forebrain region, where the degeneration of neural tissue caused by Alzheimer’s disease appears before cognitive and behavioral symptoms emerge.
A new study – the first to look at social media’s effect on memory – suggests posting personal experiences on social media makes those events much easier to recall.
Financial exploitation of older people by those who should be protecting them results in devastating health, emotional and psychological consequences. International elder abuse experts met at Weill Cornell Medicine to map out a strategy for conducting research on this problem.
Childhood poverty can cause significant psychological deficits in adulthood, according to a sweeping new study by Professor Gary Evans. The research, conducted by tracking participants over a 15-year period, is the first to show this damage occurs over time and in a broad range of ways.
Camille Sims '15 says fate brought her to Cornell and the Department of Human Development. And now it has propelled her to reign as Miss New York and to finish second runner-up in September's Miss America competition.
Brian LaGrant ’17, a human development major from New Hartford, N.Y., discusses his research on factors surrounding imitation among children and adults.
Adrienne Day writes about how Barbara Lust, professor in Human Development, and other researchers are studying changes in language patterns in early Alzheimer’s disease.
HD-Today e-News is an important portal for disseminating research and outreach from the Department of Human Development to the public. In 2016, search engine optimization (SEO) strategies were implemented to assess what information on our website attracts readers and how to increase traffic to the site. Topics that have received the most attention from visitors include the death penalty, poverty, sexual orientation, child development, brain-reward systems, the research and outreach activities of Human Development students, depression among adolescents, and women in science. SEO applications have helped direct traffic to HD-Today which has increased by over 800% and we now have visitors from the U.S., Canada, Brazil, the U.K., Germany, Russia, India, Indonesia, China, the Philippines, and Australia! We look forward to sharing with you the latest research and outreach news from the Department of Human Development.
Researchers in the social sciences have been searching for a holy grail: an accurate way to predict who is likely to engage in problematic behavior, like using drugs. Over the years experts in economics, psychology and public health have designed hundreds of questionnaires in an attempt to understand who will binge drink or have unprotected sex – and why.
Ph.D. ’15, of Vassar College, have just taken a sizable step toward answering those questions.
In a new study, Reyna and Wilhelms have debuted a new questionnaire that significantly outperforms 14 other gold-standard measures frequently used in economics and psychology. The measure’s 12 simple questions ask in various ways whether one agrees with the principle “sacrifice now, enjoy later.” Their study, “Gist of Delay of Gratification: Understanding and Predicting Problem Behaviors,” appeared Aug. 10 in the Journal of Behavioral Decision Making.
“People who get drunk frequently, party with drugs, borrow money needlessly or have unprotected sex disagreed more with the concept ‘sacrifice now, enjoy later’ than people who didn’t do these things,” Reyna said. “Instead, they leaned more toward ‘have fun today and don’t worry about tomorrow.’”
Having fun is generally good, she said. “But not being able to delay gratification can interfere with education, health and financial well-being, and the impact is greater for young people,” she added.
The questionnaire is based on Reyna’s fuzzy-trace theory. It says people boil down their personal values into a simple, qualitative “gist” of an idea – such as “sacrifice now, enjoy later.” When they have to make a life decision, they retrieve that gist and apply it to their situation.
In contrast, prevailing theory, with many questionnaires based on it, says that people make specific, quantitative trade-offs known as “delay discounting.” For example, those measures ask questions like, “Would you like $10 now or $11.50 in a week?”
“People do size up the trade-off, but they don’t make their decisions on that analysis,” Reyna said. “They think, ‘sacrifice now, benefit later.’ And therefore they study for the exam rather than go out to the party. It’s not about the party per se. It’s about the life principle.”
The researchers conducted four studies to get their results, comparing the measure, the Delay-of-Gratification Gist Scale, against 14 others. The Gist Scale’s questions include, “I wait to buy what I want until I have enough money,” “I think it is better to save money for the future” and “I am worried about the amount of money I owe.” Money is used as a “stand-in” or proxy for tempting rewards.
The first study asked 211 college students to take the Gist Scale and other measures that predict poor financial outcomes. The second and third studies, with 845 and 393 college students, respectively, compared the new measure against others involving delay discounting. With 47 teens and adult participants, the fourth study compared the Gist Scale against a widely used measure of impulsivity.
The Gist Scale is not only more accurate, it’s also shorter and simpler – some other measures are more than twice as long. It is also gender and age neutral, meaning it can be taken by anyone.
Reyna points out that cultures all over the world have aphorisms that encourage the ability to delay gratification. That skill can improve with practice, she said.
“Sometimes we send young people very mixed messages about struggle. I think it’s extremely important for them to know that struggle and pain are part of life and to be expected,” she said. “Staying the course, keeping your eyes on the prize – these values make a difference. And they can be taught and they can be practiced.”
Front and side views of two regions of interest for the origins of Alzheimer's disease - the basal forebrain, top, and the entorhinal cortex, bottom.
Alzheimer’s disease is a neurodegenerative disorder for which, despite years of research, there are no effective treatments or cures. However, recent breakthroughs in molecular genetics have shown that the disease may spread, like an infection, across closely connected areas of the brain. These findings underscore the need for research aimed at tracking its spread to the earliest points of origin in the brain, so therapies that target those areas can be developed.
An international collaboration between Nathan Spreng, Cornell assistant professor of human development and the Rebecca Q. and James C. Morgan Sesquicentennial Faculty Fellow in the College of Human Ecology, and Taylor Schmitz of the University of Cambridge’s Cognitive Brain Sciences Unit, sheds light on the basal forebrain region, where the degeneration of neural tissue caused by Alzheimer’s disease appears even before cognitive and behavioral symptoms of the disease emerge.
The basal forebrain contains very large and densely connected neurons that are particularly vulnerable to the disease. Schmitz and Spreng show that, as Alzheimer’s progresses, degeneration of the basal forebrain predicts subsequent degeneration in temporal lobe areas of the brain involved in memory. This pattern is consistent with other research showing that Alzheimer’s indeed spreads across brain regions over time, but the study challenges a widely held belief that the disease originates in the temporal lobe.
“We’re hoping that this work pushes a bit of a reorganization of the field itself, to reappraise where the disease originates,” Spreng said. “That could open up new avenues for intervention; certainly it would for detection.”
Their report is the product of a two-year study of a large sample of age-matched older adults. Within this sample, one group was cognitively normal, according to standard tests, while others were characterized by different levels of cognitive impairment:
Individuals with mild cognitive impairment (MCI) who did not progress to Alzheimer’s disease;
MCI individuals who progressed to Alzheimer’s after one year; and
Individuals classified as having Alzheimer’s throughout the duration of the study.
Through analysis of high-resolution anatomical magnetic resonance imaging of brain volumes, taken three times over the two-year study period, the researchers were able to determine that individuals with MCI or Alzheimer’s showed greater losses in gray matter volume in both the basal forebrain and temporal lobe, compared with cognitively normal controls. Intriguingly, they showed that over the two-year period, degeneration of neural tissue in the basal forebrain predicted subsequent tissue degeneration in the temporal lobe, but not the other way around.
A sampling of spinal fluid from healthy adults can detect an abnormal level of beta amyloid, indicative of Alzheimer’s, Spreng said. Test results showed that temporal lobes looked the same regardless of amyloid level, but the basal forebrain showed notable degeneration among those seemingly healthy adults with abnormal amyloid levels.
Spreng admits that being able to predict who will get the disease doesn’t mean a lot without a protocol to treat and, ultimately, cure the disease. “And it might induce more anxiety,” he said. But the more knowledge that can be gained now, he said, the better.
“Future molecular genetics work holds strong promise for developing therapeutic strategies to prevent the spread of pathology at stages of Alzheimer’s preceding cognitive decline,” Schmitz said. “Our clarification of an earlier point of Alzheimer’s propagation is therefore of utmost importance for guiding endeavors to combat this devastating disease.”
This work was funded by grants from the National Institutes of Health and the Alzheimer’s Association.